ea0029p1542.1 | Pituitary Clinical | ICEECE2012
Ligueros-Saylan M.
, Zhang Y.
, Newell-Price J.
, Petersenn S.
, Lymperopoulos S.
Background: Cushings disease is associated with high morbidity and mortality, and there are currently no approved medical therapies. Twice-daily pasireotide sc showed efficacy in patients with mostly moderate-to-severe (UFC≥2×ULN) Cushings disease in a large, randomized, double-blind, 12-month trial. A monthly long-acting release (LAR) formulation of pasireotide has been developed to provide a smoother pharmacokinetic profile, potentially a better effica...